Ceftazidime-avibactam treatment dilemma of blaKPC−2-containing Klebsiella pneumoniae due to the development of co-existence of mixed strains carrying blaKPC−2 or blaKPC−33 in lung transplant recipients
The study identified a "transitional state" of the mixed CRKP strains carrying either bla<sub>KPC-2</sub> or bla<sub>KPC-33</sub> in CAZ/AVI-exposed patients. Molecular diagnostics are crucial for identifying mixed strains and the transitional state of bla<sub>KPC</sub> variants, guiding treatment decisions in this complex landscape.
Authors
- Yiqun Ma (ORCID: https://orcid.org/0000-0001-8346-7199)
- Zichen Lei
- Yongli Wu (ORCID: https://orcid.org/0000-0001-9774-453X)
- Xinrui Yang (ORCID: https://orcid.org/0000-0002-2135-3425)
- Binghuai Lu (ORCID: https://orcid.org/0000-0003-3510-2747)
- Feilong Zhang (ORCID: https://orcid.org/0000-0002-9281-0742)
- Yulin Zhang (ORCID: https://orcid.org/0000-0002-3231-953X)
- Lingbing Zeng (ORCID: https://orcid.org/0000-0002-7073-0039)
- Xinmeng Liu
- Ziyao Li (ORCID: https://orcid.org/0000-0001-7346-2976)
- Qi Liu (ORCID: https://orcid.org/0009-0002-0475-3424)
Institutions
- Nanchang University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s12941-024-00743-x
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine