Influence of endoxifen on mammographic density: results from the KARISMA-Tam trial
We have identified a possible window of effect on mammographic breast density at endoxifen concentrations of 2-3 ng/mL in premenopausal women, which corresponds to the doses of 5 and 10 mg tamoxifen. Because mammographic breast density change was used as a surrogate marker for therapy response, results should be confirmed using clinically established outcomes measures.
Authors
- Erik Eliasson (ORCID: https://orcid.org/0000-0002-4707-4256)
- Jenny Bergqvist
- L. Magnus Bäcklund (ORCID: https://orcid.org/0000-0003-0397-6538)
- Signe Borgquist (ORCID: https://orcid.org/0000-0001-7938-8893)
- Mikael Eriksson (ORCID: https://orcid.org/0000-0001-8135-4270)
- Kamila Czene (ORCID: https://orcid.org/0000-0002-3233-5695)
- Marike Gabrielson (ORCID: https://orcid.org/0000-0002-3171-1556)
- Per Hall (ORCID: https://orcid.org/0000-0002-5640-9126)
- Cecilia Lundholm (ORCID: https://orcid.org/0000-0002-6546-3650)
- Yvonne Wengström (ORCID: https://orcid.org/0000-0001-8317-7829)
- Mattias Hammarström (ORCID: https://orcid.org/0000-0001-6608-8867)
- Alessio Crippa (ORCID: https://orcid.org/0000-0002-2254-2420)
- José Tapia (ORCID: https://orcid.org/0000-0003-0929-4319)
Institutions
- Karolinska University Hospital (SE)
- Lund University (SE)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
- Saint Göran Hospital (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1093/jnci/djae280
- Citations
- 4
- Primary Topic
- Digital Radiography and Breast Imaging
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Vetenskapsrådet