Utilizing Patient-Derived Xenografts to Model Precision Oncology for Biliary Tract Cancer
In this study, we developed a catalog of biliary tract cancer PDXs that underwent comprehensive molecular profiling and therapeutic modeling. To date, this is one of the largest collections of biliary tract cancer PDX models and will facilitate the development of personalized treatments for patients with these aggressive malignancies.
Authors
- Yasmeen Q. Rizvi (ORCID: https://orcid.org/0009-0000-2719-4093)
- Michael Kahle (ORCID: https://orcid.org/0000-0002-5982-3832)
- Hop S. Tran Cao (ORCID: https://orcid.org/0000-0001-8612-8272)
- Kurt W. Evans (ORCID: https://orcid.org/0009-0008-6823-6809)
- Timothy P. DiPeri (ORCID: https://orcid.org/0000-0003-1190-1640)
- Jordi Rodón (ORCID: https://orcid.org/0000-0001-6467-3632)
- Thuy M. Vu (ORCID: https://orcid.org/0000-0002-8163-6144)
- Lawrence N. Kwong (ORCID: https://orcid.org/0000-0001-8370-1432)
- Milind M. Javle (ORCID: https://orcid.org/0000-0001-9158-0941)
- Sunyoung S. Lee (ORCID: https://orcid.org/0000-0002-5954-5991)
- Fei Su (ORCID: https://orcid.org/0000-0001-5834-4074)
- Timothy Anthony Yap (ORCID: https://orcid.org/0000-0002-2154-3309)
- Maria Gabriela Raso (ORCID: https://orcid.org/0000-0003-2105-5556)
- Funda Meric‐Bernstam (ORCID: https://orcid.org/0000-0001-6816-6072)
- Ching‐Wei D. Tzeng (ORCID: https://orcid.org/0000-0001-6035-7288)
- Xiaofeng Zheng
- Kaushik Varadarajan (ORCID: https://orcid.org/0000-0002-4114-5498)
- Ming Zhao
- Sun-Hee Kim (ORCID: https://orcid.org/0000-0003-2582-0841)
- Huamin Wang (ORCID: https://orcid.org/0000-0002-2038-5863)
- Stephen Scott
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Loyola University Chicago (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1233
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute