A Tumor-Naïve ctDNA Assay Detects Minimal Residual Disease in Resected Stage II or III Colorectal Cancer and Predicts Recurrence: Subset Analysis from the GALAXY Study in CIRCULATE-Japan
This tumor-naïve MRD assay demonstrated clinically meaningful performance at LMT and longitudinally, accurately predicting clinical recurrence. MRD status was a stronger prognostic biomarker for disease-free survival compared with standard-of-care carcinoembryonic antigen.
Authors
- Chithra Sangli
- Richard Blidner
- Daniel Neems
- Christine Lo (ORCID: https://orcid.org/0000-0003-0969-9973)
- Robert Tell
- Jason Yamada-Hanff (ORCID: https://orcid.org/0000-0002-9331-2921)
- Yoshiaki Nakamura (ORCID: https://orcid.org/0000-0002-5241-6855)
- Ichiro Takemasa (ORCID: https://orcid.org/0000-0003-1595-2453)
- Anne Sonnenschein
- Jun Watanabe (ORCID: https://orcid.org/0000-0002-7187-3664)
- Daisuke Kotani (ORCID: https://orcid.org/0000-0002-4196-555X)
- Dana F. DeSantis (ORCID: https://orcid.org/0000-0001-5875-4962)
- Kentaro Yamazaki (ORCID: https://orcid.org/0000-0001-6269-9345)
- Farahnaz Islam (ORCID: https://orcid.org/0000-0002-8331-9871)
- Hideaki Bando (ORCID: https://orcid.org/0000-0001-5041-2765)
- Halla Nimeiri (ORCID: https://orcid.org/0000-0002-8760-6456)
- Terri M. Driessen (ORCID: https://orcid.org/0000-0002-9116-5497)
- Jonathan E. Freaney
- Masahito Kotaka (ORCID: https://orcid.org/0000-0001-5976-613X)
- Kristiyana Kaneva
- Saori Mishima (ORCID: https://orcid.org/0000-0002-5922-1487)
- Takayuki Yoshino (ORCID: https://orcid.org/0000-0002-0489-4756)
- Eiji Oki (ORCID: https://orcid.org/0000-0002-9763-9366)
- Hiroya Taniguchi (ORCID: https://orcid.org/0000-0003-1407-6682)
- Hala Boulos
- Takeshi Kato (ORCID: https://orcid.org/0000-0001-5347-550X)
- Seung Won Hyun
- Kate Sasser (ORCID: https://orcid.org/0009-0009-2804-1684)
Institutions
- Kansai Medical University (JP)
- Kyushu University (JP)
- Sapporo Medical University (JP)
- Yokohama City University Medical Center (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Shizuoka Cancer Center (JP)
- Osaka National Hospital (JP)
- Tempus Labs (United States) (US)
- Aichi Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2396
- Citations
- 14
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.99