Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma <i>In Situ</i> of the Breast
The enrichment of PV in ATM, BRCA1, BRCA2, CHEK2, and PALB2 among women with DCIS suggests that multigene panel testing may be appropriate for women with DCIS. Elevated risks of CBC in carriers of PV in high-penetrance genes with DCIS confirmed the utility of testing for surgical decision-making.
Authors
- Chunling Hu (ORCID: https://orcid.org/0000-0002-6814-4639)
- Amy Trentham‐Dietz (ORCID: https://orcid.org/0000-0002-5971-4660)
- Rachid Karam (ORCID: https://orcid.org/0000-0002-5645-498X)
- Jill S. Dolinsky (ORCID: https://orcid.org/0000-0002-3854-9539)
- A. Heather Eliassen (ORCID: https://orcid.org/0000-0002-3961-6609)
- Alpa V. Patel (ORCID: https://orcid.org/0000-0001-9997-1218)
- Fergus J. Couch (ORCID: https://orcid.org/0000-0001-9417-9985)
- Ronan E. Couch (ORCID: https://orcid.org/0009-0002-0235-6484)
- Kathryn J. Ruddy (ORCID: https://orcid.org/0000-0001-6298-332X)
- Lauren R. Teras (ORCID: https://orcid.org/0000-0003-2419-8536)
- Jeffrey N. Weitzel (ORCID: https://orcid.org/0000-0001-6714-092X)
- Marcy E. Richardson (ORCID: https://orcid.org/0000-0002-4626-4920)
- Song Yao (ORCID: https://orcid.org/0000-0001-9442-1313)
- Eric C. Polley (ORCID: https://orcid.org/0000-0002-5152-8740)
- Tina Pesaran (ORCID: https://orcid.org/0000-0001-9807-4304)
- Clara Bodelón (ORCID: https://orcid.org/0000-0002-6578-2678)
- Christine B. Ambrosone (ORCID: https://orcid.org/0000-0003-1717-9943)
- James M. Hodge (ORCID: https://orcid.org/0000-0002-6253-7394)
- Esther M. John (ORCID: https://orcid.org/0000-0003-3259-8003)
- Kristen D. Brantley (ORCID: https://orcid.org/0000-0003-0084-4775)
- Kathryn L. Penney (ORCID: https://orcid.org/0000-0002-2815-3450)
- Huaizhi Huang (ORCID: https://orcid.org/0009-0001-6186-7228)
- Peter Kraft (ORCID: https://orcid.org/0000-0002-4472-8103)
- Katie M. O’Brien (ORCID: https://orcid.org/0000-0002-1931-1349)
- Dale P. Sandler (ORCID: https://orcid.org/0000-0002-6776-0018)
- Susan L. Neuhausen (ORCID: https://orcid.org/0000-0001-5053-0390)
- Susan M. Domchek (ORCID: https://orcid.org/0000-0002-5914-7272)
- Christopher A. Haiman (ORCID: https://orcid.org/0000-0002-0097-9971)
- Celine M. Vachon
- Argyrios Ziogas (ORCID: https://orcid.org/0000-0003-4529-3727)
- Kimberly A. Bertrand (ORCID: https://orcid.org/0000-0002-4565-7618)
- Katherine L. Nathanson (ORCID: https://orcid.org/0000-0002-6740-0901)
- Hoda Anton‐Culver (ORCID: https://orcid.org/0000-0002-9603-0110)
- Siddhartha Yadav (ORCID: https://orcid.org/0000-0003-4630-9903)
- Nicholas Boddicker (ORCID: https://orcid.org/0000-0002-6784-2072)
- Janet E. Olson (ORCID: https://orcid.org/0000-0003-4944-7789)
- Julie R. Palmer (ORCID: https://orcid.org/0000-0002-6534-335X)
- David E. Goldgar (ORCID: https://orcid.org/0000-0003-0697-9347)
- Marı́a Elena Martı́nez (ORCID: https://orcid.org/0000-0002-6728-1834)
- Jie Na (ORCID: https://orcid.org/0000-0003-3435-1805)
- James V. Lacey (ORCID: https://orcid.org/0000-0002-4560-8592)
- Clarice Ring Weinberg (ORCID: https://orcid.org/0000-0002-7713-8556)
Institutions
- Boston University (US)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Roswell Park Comprehensive Cancer Center (US)
- National Institutes of Health (US)
- City Of Hope National Medical Center (US)
- Mayo Clinic (US)
- Massachusetts Department of Public Health (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of San Diego (US)
- Chicago Department of Public Health (US)
- Palo Alto University (US)
- University of California, Irvine (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- WinnMed (US)
- University of California San Diego (US)
- University of Chicago (US)
- Triangle (US)
- National Institute of Environmental Health Sciences (US)
- The University of Kansas Cancer Center (US)
- City of Hope (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- University of Kansas Medical Center (US)
- Irvine University (US)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Ambry Genetics (United States) (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1884
- Citations
- 9
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.95
Funders
- Breast Cancer Research Foundation
- National Institutes of Health
- National Cancer Institute