Randomized Phase II Study of Durvalumab with or without Tremelimumab in Patients with Metastatic Castration-Resistant Prostate Cancer
Durvalumab + tremelimumab is active in mCRPC, but patient selection remains a challenge. Further studies to develop predictive biomarkers are warranted.
Authors
- Kim N. Chi (ORCID: https://orcid.org/0000-0002-3782-7226)
- Daygen L. Finch
- Francisco Vera-Badillo (ORCID: https://orcid.org/0000-0003-1068-3258)
- Aaron R. Hansen (ORCID: https://orcid.org/0000-0002-2363-8707)
- Aly‐Khan A. Lalani (ORCID: https://orcid.org/0000-0002-9907-9112)
- Susan Ellard (ORCID: https://orcid.org/0000-0001-5757-9787)
- Michael Ong (ORCID: https://orcid.org/0000-0002-0347-5541)
- Eric Winquist (ORCID: https://orcid.org/0000-0002-8829-5979)
- Lesley Seymour (ORCID: https://orcid.org/0000-0001-8081-0799)
- Srikala S. Sridhar (ORCID: https://orcid.org/0000-0002-6994-1285)
- James Hutchenreuther (ORCID: https://orcid.org/0009-0001-5145-5721)
- Alexander W. Wyatt (ORCID: https://orcid.org/0000-0003-2399-0329)
- Nayyer Iqbal
- Sébastien J. Hotte (ORCID: https://orcid.org/0000-0001-9286-1972)
- Michael Cabanero (ORCID: https://orcid.org/0000-0001-8980-8783)
- Ming‐Sound Tsao (ORCID: https://orcid.org/0000-0002-9160-5405)
- Martin Smoragiewicz (ORCID: https://orcid.org/0000-0002-4934-6323)
- Christian Kollmannsberger (ORCID: https://orcid.org/0000-0002-6329-761X)
- Urban Emmenegger (ORCID: https://orcid.org/0000-0002-3178-1896)
- Elie Ritch (ORCID: https://orcid.org/0000-0002-3461-9157)
- Muhammad Nur Salim
- Stephen Yip
- Joel Roger Gingerich
- Christina Canil (ORCID: https://orcid.org/0000-0001-5657-6752)
- Pierre Major
Institutions
- Interior Health (CA)
- BC Cancer Agency (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of British Columbia (CA)
- Canadian Cancer Society (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Juravinski Cancer Centre (CA)
- Ottawa Hospital (CA)
- London Health Sciences Centre (CA)
- Kelowna General Hospital (CA)
- Spinal Cord Injury BC (CA)
- Princess Margaret Cancer Centre (CA)
- Western Caspian University (AZ)
- CancerCare Manitoba (CA)
- Saskatchewan Cancer Agency (CA)
- Occupational Cancer Research Centre (CA)
- Canada's Michael Smith Genome Sciences Centre (CA)
- Canadian Centre for Applied Research in Cancer Control (CA)
- Kingston Health Sciences Centre (CA)
- Baker Hughes (Canada) (CA)
- Sunnybrook Hospital (CA)
- Ottawa Hospital Research Institute (CA)
- Sunnybrook Research Institute
- University of Manitoba (CA)
- Hamilton Health Sciences (CA)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1612
- Citations
- 5
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Canadian Cancer Society