Genomic, Epigenomic, and Transcriptomic Inter- and Intratumor Heterogeneity in Desmoid Tumors
This study shows an unexpected degree of intra- and intertumor heterogeneity in desmoid tumors. Our analysis indicates that molecular analysis of a single-tumor biopsy may underestimate the magnitude of molecular alterations in desmoid tumors. Our study also shows that recurrent desmoid tumors acquire multiple new molecular alterations. Thus, molecular heterogeneity is an important consideration in drug development and validation of prognostic and predictive biomarkers for desmoid tumors.
Authors
- Benjamin Haibe‐Kains (ORCID: https://orcid.org/0000-0002-7684-0079)
- Justin Cates (ORCID: https://orcid.org/0000-0002-7336-5196)
- Gregory W. Charville (ORCID: https://orcid.org/0000-0002-2774-2704)
- Kristen N. Ganjoo (ORCID: https://orcid.org/0000-0003-0452-9967)
- Matt van de Rijn (ORCID: https://orcid.org/0000-0002-1909-9739)
- Joanna Przybył (ORCID: https://orcid.org/0000-0002-8162-5226)
- Pegah Rahimizadeh (ORCID: https://orcid.org/0000-0001-5828-8172)
- Christopher Eeles (ORCID: https://orcid.org/0000-0002-9962-7385)
- Sujay Vennam (ORCID: https://orcid.org/0000-0001-6312-1238)
- Thomas Stricker (ORCID: https://orcid.org/0000-0002-3602-9994)
- Chelsea De Bellis
- Jenny Hoffman
Institutions
- University of Toronto (CA)
- McGill University Health Centre (CA)
- Princess Margaret Cancer Centre (CA)
- Vector Institute (CA)
- Tennessee Department of Health (US)
- Tennessee Oncology (US)
- Stanford Medicine (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- McGill University (CA)
- Stanford University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1240
- Citations
- 1
- Primary Topic
- Soft tissue tumor case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Desmoid Tumor Research Foundation