Homobarrelenones: Versatile Building Blocks for the Construction of Novel and Structurally Diverse Scaffolds
Abstract We describe the derivatization of tropolone–based homobarrelenones through simple transformations, including catalytic hydrogenations, base‐catalyzed solvolysis, and hydride reductions. Despite being structurally complex and highly functionalized, the novel compounds had no significant cytotoxicity in sperm motility assays, underscoring the importance of Michael acceptor moieties in the biological activity of this class of compounds.
Authors
- Mauricio Cabrera (ORCID: https://orcid.org/0000-0002-1709-0474)
- Hugo do Carmo
- Guillermo Moyna (ORCID: https://orcid.org/0000-0002-0727-1079)
- Valeria Lucero
- G. Vallejo Fernandez (ORCID: https://orcid.org/0009-0007-6289-6075)
- Macarena Eugui (ORCID: https://orcid.org/0009-0009-6111-7097)
Institutions
- Universidad de la República de Uruguay (UY)
- Universidad Nacional del Litoral (AR)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1002/ejoc.202400887
- Primary Topic
- Synthesis and properties of polymers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Investigación e Innovación
- Comisión Sectorial de Investigación Científica