Unraveling the impact of host genetics and factors on the urinary microbiome in a young population
The urinary microbiome, essential to human health, reveals its unique qualities in our study of 1,579 Chinese individuals. We identified distinctive microbial profiles, or "urotypes," and uncovered strong gender-related influences, particularly from sex hormones, on these microbial communities. Our research highlights significant genetic associations affecting specific urinary bacteria, indicating a deep interaction between our genetics and our microbiome. These insights not only enhance our understanding of the urinary microbiome's role in health and disease but also open new pathways for personalized medical strategies, making our findings crucial for future diagnostic and therapeutic innovations. This work underscores the intricate relationship between our body's biological processes and the microorganisms within, providing valuable knowledge for both scientific and medical communities.
Authors
- Huanming Yang (ORCID: https://orcid.org/0000-0002-0858-3410)
- Liang Xiao (ORCID: https://orcid.org/0000-0003-0836-4397)
- Ruijin Guo (ORCID: https://orcid.org/0000-0001-7863-3797)
- Haorong Lu (ORCID: https://orcid.org/0000-0003-0132-8166)
- Leying Zou (ORCID: https://orcid.org/0000-0002-7243-8410)
- Yanmei Ju (ORCID: https://orcid.org/0000-0002-1600-3164)
- Huijue Jia (ORCID: https://orcid.org/0000-0002-3592-126X)
- Xin Tong (ORCID: https://orcid.org/0000-0002-4849-6522)
- Xin Jin (ORCID: https://orcid.org/0000-0001-7554-4975)
- Jian Wang
- Xiaomin Liu (ORCID: https://orcid.org/0000-0003-2155-3627)
- Zhe Zhang (ORCID: https://orcid.org/0000-0003-3983-1226)
- Xun Xu (ORCID: https://orcid.org/0000-0002-5338-5173)
- Tao Zhang (ORCID: https://orcid.org/0000-0003-2765-2802)
- Junhong Chen (ORCID: https://orcid.org/0000-0002-8313-8317)
- Yang Zong (ORCID: https://orcid.org/0000-0002-0690-5439)
Institutions
- BGI Group (China) (CN)
- Fudan University (CN)
- IBM Research - Thomas J. Watson Research Center (US)
- Botswana Geoscience Institute (BW)
- Human Computer Interaction (Switzerland) (CH)
- China National GeneBank (CN)
- G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (RU)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
Publication Details
- Journal
- mBio
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1128/mbio.02773-24
- Citations
- 6
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- National Natural Science Foundation of China