Genomic diversity of <i>Salmonella</i> Typhimurium and its monophasic variant in pig and pork production in France
Salmonellosis is a leading cause of bacterial infection in humans and animals around the world. This study provides a snapshot of the genomic diversity of one of the most prevalent <i>Salmonella</i> serovars (<i>Salmonella</i> Typhimurium and <i>Salmonella</i> 4,[5],12:i:-) circulating on French pig farms between 2013 and 2021. We investigated the link between geographical and genomic diversity. The analyses revealed little diversity of the strains, suggesting that one or two clones are spreading within French pig herds. We also <i>in silico</i> screened genetic elements that could explain the prevalence of these strains among farmed pigs and in the slaughterhouse environment. Finally, the comparison with isolates from other countries highlighted the genomic specificity of these two French sequence type 34 clones. This work provides new insights into the dynamics of <i>S</i>. Typhimurium and <i>S</i>. 4,[5],12:i:- sampled from pig herds and slaughterhouses in France, thus laying the foundations for future analyses.
Authors
- Carole Feurer
- Sabrina Cadel-Six (ORCID: https://orcid.org/0000-0001-5291-2181)
- Karol Romero
- Madeleine De Sousa Violante (ORCID: https://orcid.org/0000-0003-1521-0265)
- Michel‐Yves Mistou (ORCID: https://orcid.org/0000-0001-9732-3970)
- Ludovic Mallet (ORCID: https://orcid.org/0000-0002-3246-389X)
- Valérie Michel (ORCID: https://orcid.org/0000-0003-0681-5588)
Institutions
- Center for Food Safety and Applied Nutrition (US)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Roche (France) (FR)
- Institut du Porc (FR)
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
- Actalia (France) (FR)
- Mathématiques et Informatique Appliquées du Génome à l'Environnement (FR)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1128/spectrum.00526-24
- Citations
- 2
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Ministère de l’Agriculture, de l’Agroalimentaire et de la Forêt
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail