Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study
Our findings provide a comprehensive analysis of aging-related factors across multiple platforms, delineating their complex interconnections. This study is the first to report novel signatures in lipidomics, gut microbiome and blood biomarkers specifically associated with PhenoAgeAccel. These insights are invaluable in understanding the molecular and metabolic mechanisms underlying biological aging and shed light on potential interventions to mitigate accelerated biological aging by targeting modifiable factors.
Authors
- Karen Tan (ORCID: https://orcid.org/0000-0002-7768-037X)
- Bryan Ng (ORCID: https://orcid.org/0000-0002-6819-0176)
- Jun Shi Lai (ORCID: https://orcid.org/0000-0002-9993-8415)
- Yap Seng Chong (ORCID: https://orcid.org/0000-0002-7232-8473)
- Johan G. Eriksson (ORCID: https://orcid.org/0000-0002-2516-2060)
- Shiao‐Yng Chan (ORCID: https://orcid.org/0000-0002-3530-3023)
- S. Sendhil Velan (ORCID: https://orcid.org/0000-0002-4096-0722)
- Li Chen (ORCID: https://orcid.org/0000-0003-1462-1695)
- Sartaj Ahmad Mir (ORCID: https://orcid.org/0000-0001-6032-0936)
- Min Gong (ORCID: https://orcid.org/0009-0001-3190-8703)
- Priti Mishra (ORCID: https://orcid.org/0000-0001-5431-1574)
- Jadegoud Yaligar (ORCID: https://orcid.org/0000-0002-6050-5241)
- Michael J. Meaney (ORCID: https://orcid.org/0000-0002-8605-1997)
- Shirong Cai (ORCID: https://orcid.org/0000-0002-0650-2234)
- Kothandaraman Narasimhan (ORCID: https://orcid.org/0000-0002-9287-4260)
- Kok Hian Tan (ORCID: https://orcid.org/0000-0003-1945-0266)
- Navin Michael (ORCID: https://orcid.org/0000-0002-6170-2108)
- Melvin Khee‐Shing Leow (ORCID: https://orcid.org/0000-0002-2837-5889)
- Jia Xu (ORCID: https://orcid.org/0000-0002-3341-7668)
- Mya Thway Tint (ORCID: https://orcid.org/0000-0002-9548-7186)
- Suresh Anand Sadananthan (ORCID: https://orcid.org/0000-0001-5938-1694)
- Jerry Chan
Institutions
- Agency for Science, Technology and Research (SG)
- University of Helsinki (FI)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Douglas Mental Health University Institute (CA)
- Tan Tock Seng Hospital (SG)
- Singapore Institute for Clinical Sciences (SG)
- KK Women's and Children's Hospital (SG)
- Duke-NUS Medical School (SG)
- National University Hospital (SG)
- Folkhälsans Forskningscentrum (FI)
- McGill University (CA)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s13073-024-01403-7
- Citations
- 10
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 11.09
Funders
- National Research Foundation
- National Research Foundation Singapore
- National University Health System
- Medical Research Council
- National Medical Research Council
- Precursory Research for Embryonic Science and Technology