Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
SCLC is highly aggressive, with limited effective treatment options. We show that ablating sympathetic nerves or inhibiting the ADRB2 receptor slows SCLC progression and prolongs survival in mice. Additionally, ADRB2 inhibition reduces the growth of human SCLC organoids and xenografts by disrupting PKA signaling, identifying a new therapeutic target.
Authors
- Tala FNU
- Qi‐Yue Chen (ORCID: https://orcid.org/0000-0001-6391-4043)
- Yinshan Fang (ORCID: https://orcid.org/0000-0001-9249-4498)
- Yuefeng Huang
- Xuebing Wu (ORCID: https://orcid.org/0000-0003-0369-5269)
- Anjali Saqi (ORCID: https://orcid.org/0000-0003-3133-9886)
- Jianwen Que (ORCID: https://orcid.org/0000-0002-6540-6701)
- Wanwei Zhang (ORCID: https://orcid.org/0000-0001-9949-1206)
- Chao Lü (ORCID: https://orcid.org/0000-0003-0982-8122)
- Timothy C. Wang (ORCID: https://orcid.org/0000-0001-5730-3019)
- Dian Yang (ORCID: https://orcid.org/0000-0002-8455-0047)
- Sanny S.W. Chung (ORCID: https://orcid.org/0000-0003-0481-4557)
- Peiguo Shi (ORCID: https://orcid.org/0000-0001-7177-8336)
- Christopher B. Damoci (ORCID: https://orcid.org/0000-0001-8308-354X)
Institutions
- Fujian Medical University (CN)
- Columbia University Irving Medical Center (US)
- Union Hospital (US)
- Union Hospital (CN)
- Columbia University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0718
- Citations
- 21
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 8.10
Funders
- National Institutes of Health