Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections
Repeated viral infections induce an immune training response in bronchial epithelial cells. Training-sensitive DNAm sites indicate alternate divergent associations in asthma compared to healthy individuals. Our novel model presents a robust tool for identifying trainable genes, providing a foundation for future studies.
Authors
- Thomas Bahmer (ORCID: https://orcid.org/0000-0002-7677-7057)
- Folke Brinkmann (ORCID: https://orcid.org/0000-0002-4307-4232)
- Matthias Kopp (ORCID: https://orcid.org/0000-0003-1989-5492)
- Marua Abu Risha (ORCID: https://orcid.org/0009-0005-6614-9136)
- Ruth Grychtol (ORCID: https://orcid.org/0000-0002-8084-104X)
- Klaus F. Rabe (ORCID: https://orcid.org/0000-0002-7020-1401)
- Nicole Maison (ORCID: https://orcid.org/0000-0002-8731-4218)
- Anna‐Maria Dittrich (ORCID: https://orcid.org/0000-0002-9582-1025)
- Erika von Mutius (ORCID: https://orcid.org/0000-0002-8893-4515)
- Uta Jappe (ORCID: https://orcid.org/0000-0001-5602-3672)
- Bianca Schaub (ORCID: https://orcid.org/0000-0003-1652-8873)
- Constanze A. Jakwerth (ORCID: https://orcid.org/0000-0002-2902-0393)
- Karri V. V. S. Narayana Reddy (ORCID: https://orcid.org/0000-0001-9002-6930)
- Silke Meiners (ORCID: https://orcid.org/0000-0003-3678-7995)
- Markus Weckmann (ORCID: https://orcid.org/0000-0001-5342-979X)
- Sai Sneha Priya Nemani
- Gesine Hansen (ORCID: https://orcid.org/0000-0001-5185-9454)
- Carsten B. Schmidt‐Weber (ORCID: https://orcid.org/0000-0002-3203-8084)
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- Helmholtz Zentrum München (DE)
- Medizinische Hochschule Hannover (DE)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- Universitäres Kinderwunschzentrum Lübeck (DE)
- University Hospital Schleswig-Holstein (DE)
- University Children’s Hospital Bern (CH)
- Research Center Borstel - Leibniz Lung Center (DE)
- German Center for Lung Research (DE)
- LungenClinic Grosshansdorf (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Allergy
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1111/all.16388
- Citations
- 9
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 2.16
Funders
- Federalno Ministarstvo Obrazovanja i Nauke
- Deutsches Zentrum für Lungenforschung