STK11 mutation affects tumor proliferation by impacting CD4+ T cell activity in lung adenocarcinoma
This study revealed the regulatory mechanism of STK11 mutation affecting tumor proliferation by impacting CD4<sup>+</sup> T cell activity in LUAD. It suggested that STK11 may be a possible biological target for LUAD patients, and inhibiting STK11 mutation or cutting off its regulatory pathway for immune function may be an effective strategy for STK11-mutated tumor patients.
Authors
- Feng Zhu (ORCID: https://orcid.org/0000-0003-1172-0102)
- Zhihui Xu (ORCID: https://orcid.org/0000-0002-5637-2503)
- Jing Ge (ORCID: https://orcid.org/0000-0001-9679-1262)
- Qing‐bao Chi
- Zhenye Lv
- Rui Feng
Institutions
- Wenzhou City People's Hospital (CN)
Publication Details
- Journal
- Central European Journal of Immunology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.5114/ceji.2024.143578
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Zhejiang Province