[High RNF7 expression enhances PD-1 resistance of non-small cell lung cancer cells by promoting CXCL1 expression and myeloid-derived suppressor cell recruitment <i>via</i> activating NF-κB signaling].
High expression of RNF7 in NSCLC cells promotes CXCL1 expression by activating the NF-κB signaling pathway, thus leading to the chemotactic recruitment of MDSCs, which contributes to tumor resistance to antiPD-1 therapy.
Authors
- Bin Geng (ORCID: https://orcid.org/0000-0002-1505-3645)
- Wenying Zhao (ORCID: https://orcid.org/0000-0001-8774-144X)
- Zhou Sun (ORCID: https://orcid.org/0000-0001-5015-7629)
- Nanshan Zhong (ORCID: https://orcid.org/0000-0003-2274-1427)
- Haisheng Wang (ORCID: https://orcid.org/0000-0002-5133-9587)
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-09-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.09.10
- Primary Topic
- interferon and immune responses
- Type
- article