[Effects of chronic intermittent hypoxia and reoxygenation on insulin resistance and skeletal muscle miR-27a-3p/PPARγ/IRS1/PI3K/AKT expressions in rats].
CIH increases IR, causes skeletal muscle pathology, downregulates miR-27a-3p expression, upregulates PPARγ expression, and inhibits IRS1/PI3K/AKT insulin signaling in the skeletal muscles of rats, and these changes can be reversed by reoxygenation. MiR-27a-3p may participate in CIH-induced IR by modulating the PPAR γ/IRS1/PI3K/AKT signaling pathway.
Authors
- Wenpei Bai (ORCID: https://orcid.org/0000-0002-1050-8460)
- Min Jin (ORCID: https://orcid.org/0000-0003-0188-0292)
- Qingwei Chen (ORCID: https://orcid.org/0000-0002-5458-0210)
- Huiqi Li (ORCID: https://orcid.org/0000-0002-1127-0829)
- Chao Wei (ORCID: https://orcid.org/0000-0002-7425-5132)
- Chongqi Jia
- Xi Zhou
Institutions
- Baotou Medical College (CN)
- Dawu County People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-09-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.09.13
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article