A stealthy neural recorder for the study of behaviour in primates
By monitoring brain neural signals, neural recorders allow for the study of neurological mechanisms underlying specific behavioural and cognitive states. However, the large brain volumes of non-human primates and their extensive range of uncontrolled movements and inherent wildness make it difficult to carry out covert and long-term recording and analysis of deep-brain neural signals. Here we report the development and performance of a stealthy neural recorder for the study of naturalistic behaviours in non-human primates. The neural recorder includes a fully implantable wireless and battery-free module for the recording of local field potentials and accelerometry data in real time, a flexible 32-electrode neural probe with a resorbable insertion shuttle, and a repeater coil-based wireless-power-transfer system operating at the body scale. We used the device to record neurobehavioural data for over 1 month in a freely moving monkey and leveraged the recorded data to train an artificial intelligence model for the classification of the animals' eating behaviours.
Authors
- Doyoung Lee (ORCID: https://orcid.org/0000-0001-9950-0512)
- Janghwan Jekal (ORCID: https://orcid.org/0009-0001-9590-2853)
- Youngjeon Lee (ORCID: https://orcid.org/0000-0002-5387-3441)
- Junwoo Yea (ORCID: https://orcid.org/0009-0000-3104-6018)
- Jae‐Woong Jeong (ORCID: https://orcid.org/0000-0001-7607-5453)
- Kyung Seob Lim (ORCID: https://orcid.org/0000-0002-9117-887X)
- Jieun Son (ORCID: https://orcid.org/0000-0001-9862-7706)
- Tae Sang Yu
- Hyeokjun Lee
- Junghyung Park (ORCID: https://orcid.org/0000-0002-4967-8512)
- Saehyuck Oh (ORCID: https://orcid.org/0009-0003-4177-5101)
- Sheng Xu (ORCID: https://orcid.org/0000-0002-3120-4992)
- Jinyoung Won (ORCID: https://orcid.org/0000-0001-5112-6736)
- Ji‐Woong Choi (ORCID: https://orcid.org/0000-0001-9109-3860)
- Hyeon-Gu Yeo (ORCID: https://orcid.org/0000-0002-6600-6291)
- Young Min Song (ORCID: https://orcid.org/0000-0002-4473-6883)
- Han Hee Jung (ORCID: https://orcid.org/0000-0002-9757-5649)
- Chang‐Yeop Jeon (ORCID: https://orcid.org/0000-0002-8229-7068)
- Jong‐Cheol Rah (ORCID: https://orcid.org/0000-0003-3780-0522)
- Kyung‐In Jang (ORCID: https://orcid.org/0000-0002-4664-5029)
- Bong Hoon Kim (ORCID: https://orcid.org/0000-0002-4610-0176)
- Leslie Jaesun Ha (ORCID: https://orcid.org/0000-0001-8559-5434)
- Jeongdae Ha (ORCID: https://orcid.org/0000-0002-3162-1390)
- Hyung Jin Choi (ORCID: https://orcid.org/0000-0003-0593-6978)
- Soojeong Song
- Sanghoon Lee (ORCID: https://orcid.org/0000-0001-8989-6939)
- Jungmin Lee (ORCID: https://orcid.org/0000-0003-3137-4163)
- Jaehong Lee (ORCID: https://orcid.org/0000-0002-8779-5293)
- Young Hee Lee (ORCID: https://orcid.org/0000-0003-0633-9841)
- Jin‐Mo Kim (ORCID: https://orcid.org/0000-0001-9766-5874)
- Yu Gyeong Kim (ORCID: https://orcid.org/0000-0003-4907-3756)
Institutions
- Seoul National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- University of California San Diego (US)
- Gwangju Institute of Science and Technology (KR)
- Hertie Institute for Clinical Brain Research (DE)
- Korea Brain Research Institute (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Nature Biomedical Engineering
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1038/s41551-024-01280-w
- Citations
- 22
- Primary Topic
- Neural dynamics and brain function
- Type
- article
- Field-Weighted Citation Impact
- 7.54
Funders
- Korea Research Institute of Bioscience and Biotechnology
- National Research Council of Science and Technology