Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept
Collectively, our results show that (R)-AS-1 has favorable tolerability and provides robust preclinical efficacy against seizures. Thus, allosteric enhancement of EAAT2 function could offer a novel therapeutic strategy for treatment of epilepsy and potentially other neurological disorders associated with glutamate excitotoxicity. ANN NEUROL 2025;97:344-357.
Authors
- Alexander Rotenberg (ORCID: https://orcid.org/0000-0002-6495-5928)
- Rhea Temmermand
- Agata Faron‐Górecka (ORCID: https://orcid.org/0000-0002-8202-190X)
- Katelyn Reeb
- Michał Abram (ORCID: https://orcid.org/0000-0001-9738-3359)
- Marcin Jakubiec (ORCID: https://orcid.org/0000-0002-6602-3825)
- Mirosław Zagaja (ORCID: https://orcid.org/0000-0002-0079-0490)
- Katarzyna Socała (ORCID: https://orcid.org/0000-0001-7706-2080)
- Marta Andres‐Mach (ORCID: https://orcid.org/0000-0003-4107-9184)
- Andréia C. K. Fontana (ORCID: https://orcid.org/0000-0002-4791-8746)
- Magdalena Kolasa (ORCID: https://orcid.org/0000-0002-2023-2699)
- Maciej Maj (ORCID: https://orcid.org/0000-0002-3435-2544)
- Rafał M. Kamiński (ORCID: https://orcid.org/0000-0002-1632-4101)
- Mustafa Qadir Hameed (ORCID: https://orcid.org/0000-0003-4004-5564)
- Aleksandra Szewczyk (ORCID: https://orcid.org/0000-0001-8013-3361)
- Krzysztof Kamiński (ORCID: https://orcid.org/0000-0003-2103-371X)
Institutions
- Medical University of Lublin (PL)
- Jagiellonian University (PL)
- Boston Children's Hospital (US)
- Harvard University (US)
- Maria Curie-Skłodowska University (PL)
- Maj Institute of Pharmacology (PL)
- Medicina (PL)
- Instytut Medycyny Wsi im. Witolda Chodźki (PL)
- Drexel University (US)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1002/ana.27124
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Drexel University
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke