Nickel-Catalyzed Direct Fluorosulfonylation of Vinyl Bromides and Benzyl Bromides for Sulfonyl Fluorides
An efficient nickel-catalyzed direct fluorosulfonylation of vinyl bromides and benzyl bromides under mild reaction conditions has been developed for sulfonyl fluorides utilizing Na<sub>2</sub>S<sub>2</sub>O<sub>4</sub> and NFSI as the sulfur dioxide and fluorine sources, respectively. This reaction system tolerates organic bromide compounds, such as β-styryl bromides, alkyl vinyl bromides, and benzyl bromides, to achieve corresponding sulfonyl fluorides in moderate to good yields, with convenient operation, mild conditions, broad substrate scope, good functional group compatibility, and excellent retention of configuration to vinyl bromides.
Authors
- Changge Zheng (ORCID: https://orcid.org/0000-0001-7047-1594)
- Kui Zhao (ORCID: https://orcid.org/0000-0002-9512-0405)
- Ruilong Feng
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-2139-3152)
- Chongbin Wei
- Feng Zheng
- Chunxiang Li (ORCID: https://orcid.org/0000-0003-3775-4167)
- Jianquan Hong (ORCID: https://orcid.org/0000-0001-9212-6425)
- Xifei Chen
- Xinxin Gong
Institutions
- Jiangnan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1021/acs.orglett.4c03820
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities