Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age
Melatonin supplementation significantly improved IVF outcomes in women of advanced maternal age, particularly those ≥ 38 years old, likely by modulating cuproptosis and ferroptosis and enhancing mitochondrial function in cumulus and granulosa cells. These results suggest that melatonin could be a promising adjuvant therapy for improving IVF success rates in older women.
Authors
- Li‐Te Lin (ORCID: https://orcid.org/0000-0001-5063-6793)
- Kuan‐Hao Tsui (ORCID: https://orcid.org/0000-0001-8090-8657)
- Chia‐Jung Li (ORCID: https://orcid.org/0000-0002-3773-9015)
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University of Science and Technology (TW)
- Taipei Veterans General Hospital (TW)
- Tajen University (TW)
- National Yang Ming University Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s12958-024-01311-w
- Citations
- 21
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 23.30
Funders
- Kaohsiung Veterans General Hospital
- National Science and Technology Council