Western Blot Characterization of Human Serum Prestin, an Outer Hair Cell Biomarker
Western blot characterization of OHC biomarker prestin in humans shows that the band closest to the previously estimated molecular weight of prestin (81 kDa) is related to a functional measure of OHCs. This finding increases confidence in the value of serum prestin as a biomarker. The Western blot method appears to offer higher-resolution information on serum prestin. Future work will be carried out under pathological conditions to inform on the application of this quantitative method in clinical settings.
Authors
- Kourosh Parham (ORCID: https://orcid.org/0000-0002-4024-6019)
- Heather M. McClure (ORCID: https://orcid.org/0000-0002-4441-5609)
- Erika Skoe (ORCID: https://orcid.org/0000-0001-7500-5197)
- Mohsin Mirza (ORCID: https://orcid.org/0000-0001-8399-7368)
- Patrick Adamczyk
Institutions
- University of Connecticut (US)
Publication Details
- Journal
- Otology & Neurotology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1097/mao.0000000000004371
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.36