Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments
Luteolin had a good anti-NSCLC effect, and the apoptosis-inducing effect might be related to the Akt/MDM2/p53 signaling pathway.
Authors
- Zhenpeng Shi
- Deshan Liu (ORCID: https://orcid.org/0000-0001-9926-1478)
- Jing Tang (ORCID: https://orcid.org/0000-0002-7580-9459)
- Changling Li (ORCID: https://orcid.org/0000-0002-2260-8733)
- Yun Qiao (ORCID: https://orcid.org/0000-0002-6145-8651)
- Zixuan Ren (ORCID: https://orcid.org/0000-0002-9141-5919)
- Zhenguo Liu (ORCID: https://orcid.org/0000-0002-9917-6684)
- Wenyi Li (ORCID: https://orcid.org/0000-0001-8627-2346)
- Junyu Zhou (ORCID: https://orcid.org/0000-0001-9392-5296)
- Jihang Zhang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.3389/fonc.2024.1471109
- Citations
- 11
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.98