Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis
These findings suggested that rabeprazole induced ferroptosis to reduce CDX2 expression in gastric epithelial cells through PKA/CREB cascade signaling, implying that targeting ferroptosis could be a promising strategy in improving gastric intestinal metaplasia during <i>H. pylori</i>-infected patients.
Authors
- Zijun Lin (ORCID: https://orcid.org/0000-0002-4299-9153)
- Lanlan Geng (ORCID: https://orcid.org/0000-0002-0336-952X)
- Fengfeng Zheng
- Fangfang Xie (ORCID: https://orcid.org/0000-0003-2668-460X)
- Sitang Gong (ORCID: https://orcid.org/0000-0002-6899-0616)
- Wanfu Xu (ORCID: https://orcid.org/0009-0009-4747-459X)
- Xiang Li (ORCID: https://orcid.org/0000-0002-4239-3733)
- Jing Xie (ORCID: https://orcid.org/0000-0001-8156-0322)
- Shuping Xie
- Fangying Yang
- Canxin Huang
- Xinhua Liang
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Putian University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3389/fphar.2024.1409001
- Citations
- 3
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province