Dexamethasone is a regulator of clock genes in testicular peritubular cells
The results indicate that an internal clock system likely exists in peritubular cells of the testis and that Dex, via testicular GR expressed by peritubular cells and other somatic cells, is a strong regulator of this system. In a physiological situation, GC thus may be important regulators of the testicular clock, while in a situation of prolonged stress or GC-medication, derangements in clock gene expression may result.
Authors
- Thomas Fröhlich (ORCID: https://orcid.org/0000-0002-4709-3211)
- Matthias Trottmann (ORCID: https://orcid.org/0000-0001-9926-867X)
- Rüdiger Behr (ORCID: https://orcid.org/0000-0001-8816-6619)
- Stoyan Petkov (ORCID: https://orcid.org/0000-0001-7551-7862)
- Youli K. Stepanov (ORCID: https://orcid.org/0000-0001-5534-8539)
- H. Welter
- Ulrich Pickl
- Artur Mayerhofer (ORCID: https://orcid.org/0000-0002-9388-4639)
- Michaela Schneider
- Nicole Kreitmair
- Julia Schneider (ORCID: https://orcid.org/0000-0002-3007-4348)
- Frank‐Michael Köhn
Institutions
- German Primate Center (DE)
- Institut für Urheber- und Medienrecht (DE)
- Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Andrology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1111/andr.13788
- Citations
- 2
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Deutsche Forschungsgemeinschaft