Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts
The present study provides new general insights into the complexity of the PDAC microenvironment by defining phenotypic heterogeneities and spatial distributions of CAFs, thus suggesting different functions of their subtypes in the PDAC microenvironment.
Authors
- Subhra K. Biswas
- Luigi Terracciano (ORCID: https://orcid.org/0000-0002-9393-9660)
- Cecília Garlanda (ORCID: https://orcid.org/0000-0002-1510-7703)
- Alberto Mantovani (ORCID: https://orcid.org/0000-0001-5578-236X)
- Andrea Doni (ORCID: https://orcid.org/0000-0001-9203-5814)
- Maria Rita Fumagalli (ORCID: https://orcid.org/0000-0003-3404-5779)
- Raffaella D’Anna
- Mauro Sollai (ORCID: https://orcid.org/0000-0003-1527-9342)
- Lorenza Rimassa (ORCID: https://orcid.org/0000-0001-9957-3615)
- Alessandro Zerbi (ORCID: https://orcid.org/0000-0002-9176-0448)
- Silvia Bozzarelli (ORCID: https://orcid.org/0000-0002-8118-7342)
- Marco Erreni (ORCID: https://orcid.org/0000-0002-1922-0818)
- Raffaella Parente (ORCID: https://orcid.org/0000-0003-3607-1380)
- Damiano Zanini (ORCID: https://orcid.org/0000-0002-7156-2225)
- Gennaro Nappo (ORCID: https://orcid.org/0000-0002-6048-898X)
Institutions
- Agency for Science, Technology and Research (SG)
- Humanitas University (IT)
- Queen Mary University of London (GB)
- Singapore Immunology Network (SG)
- William Harvey Research Institute (GB)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3389/fimmu.2024.1472433
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Ministero della Salute
- Ministero degli Affari Esteri e della Cooperazione Internazionale
- Humanitas Research Hospital
- FP7 International Cooperation