The role of SIRT1-FXR signaling pathway in valproic acid induced liver injury: a quantitative targeted metabolomic evaluation in epileptic children
Nineteen identified metabolites showed a strong association with hepatotoxicity and three bile acid metabolites changed with the development of liver injury. The SIRT1-FXR pathway was firstly proposed to participate in VPA-induced hepatotoxicity.
Authors
- Mingming Zhao (ORCID: https://orcid.org/0000-0003-4566-9608)
- Guofei Li (ORCID: https://orcid.org/0000-0001-6194-541X)
- Limei Zhao (ORCID: https://orcid.org/0000-0001-8573-8028)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3389/fphar.2024.1477619
- Citations
- 6
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.66