IGF2BP3/CTCF Axis–Dependent NT5DC2 Promotes M2 Macrophage Polarization to Enhance the Malignant Progression of Lung Squamous Cell Carcinomas
The IGF2BP3/CTCF axis-dependent NT5DC2 promotes M2 macrophage polarization, thereby enhancing the malignant progression of LUSC. This study was the first to reveal the role of NT5DC2 in LUSC and the underlying mechanism. The result suggests that targeting the IGF2BP3/CTCF/NT5DC2 axis may have clinical significance in the treatment of LUSC.
Authors
- Xiaoxuan Sun
- Zhanbo Wu
- Jifeng Sun (ORCID: https://orcid.org/0000-0003-0106-528X)
- Ran Zhang (ORCID: https://orcid.org/0000-0002-0921-078X)
- Yuwen Wang (ORCID: https://orcid.org/0000-0002-7612-7935)
- Hao Wang (ORCID: https://orcid.org/0000-0003-0773-4528)
- Jun Wang (ORCID: https://orcid.org/0009-0007-5139-2330)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- The Clinical Respiratory Journal
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1111/crj.70031
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47