ZNF350 gene polymorphisms promote the response to Peg-IFNα therapy through JAK-STAT signaling pathway in patients with chronic hepatitis B
The G allele of rs2278420 and rs6509607 were associated with mRNA level of ZNF350, with an increased probability of Peg-IFNα response in HBeAg-positive CHB patients, likely through the modulation of JAK-STAT signaling pathway.
Authors
- Yongbin Zeng (ORCID: https://orcid.org/0000-0002-4355-0710)
- Ya Fu (ORCID: https://orcid.org/0000-0002-7630-4233)
- Tianbin Chen (ORCID: https://orcid.org/0000-0002-9136-2167)
- Jianhui Guo (ORCID: https://orcid.org/0000-0002-7112-9958)
- Shaoying Guo
- Qishui Ou
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.3389/fimmu.2024.1488055
- Citations
- 2
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- Fujian Medical University