Preparation of an Injectable Thermosensitive Pluronic <scp>F127</scp>/ γ‐<scp>Fe₂O₃</scp> Hydrogel for Combined Hyperthermia and Localized Drug Delivery for Cancer Treatment

ABSTRACT A novel locally injectable hydrogel made from Pluronic F127 containing magnetic γ‐Fe 2 O 3 nanoparticles (GMNP) and Doxorubicin (DOX) with temperature‐sensitive properties for localized magnetic hyperthermia and drug delivery was prepared. In most of the studies that have been observed so far, magnetic nanoparticles have been injected as ferrofluid solutions, but because of the high osmotic pressure inside the tumor, there is a high risk of injection leakage and ferrofluid redistribution. Also, due to the super‐paramagnetic property of nanoparticles, the probability of their agglomeration increases, which causes Atherosclerosis and other problems. The DOX/GMNP/F127 hydrogel exhibited a hyperthermia effect and showed an increase in temperature by applying ACMF (400 kHz). The shape of the GMNPs was spherical, and their size was about 19–51 nm. The mixture was produced as liquid outside the body, but it turned into a gel by increasing the temperature to body temperature. Applying an AC magnetic field on the DOX/GMNP/F127‐gel not only produced controllable heat but also increased the rate of drug release from the gel. Mixing magnetic GMNPs with anticancer DOX drug in the thermo‐responsive F127 hydrogel has emerged as a promising smart combination for the application of simultaneous magnetic hyperthermia and chemotherapy in the possible treatment of cancer.