Mu‐opioid receptors in tachykinin‐1‐positive cells mediate the respiratory and antinociceptive effects of the opioid fentanyl
Our findings suggest that Tac1-positive cells mediate the respiratory depressive and antinociceptive effects of the opioid fentanyl, providing important insights for the development of pain therapies with reduced risk of respiratory side effects.
Authors
- Andreea Furdui
- Gaspard Montandon (ORCID: https://orcid.org/0000-0003-3587-4472)
- Carolina da Silveira Scarpellini (ORCID: https://orcid.org/0000-0001-5576-3468)
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1111/bph.17369
- Citations
- 1
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Canadian Institutes of Health Research
- Institute of Circulatory and Respiratory Health