Design, Synthesis, and Molecular Docking of Quinazolines Bearing Caffeoyl Moiety for Targeting of PGK1/PKM2/STAT3 Signaling Pathway in the Human Breast Cancer
The results show that compounds 2 and 3 induce apoptotic activity by blocking the PGK1- PKM2-STAT3 signaling pathway. The present investigation opens exciting possibilities for developing innovative new anticancer quinazolines bearing caffeoyl moiety.
Authors
- Mohammed A. Hussein (ORCID: https://orcid.org/0000-0002-1811-2794)
- Rita M. Borik (ORCID: https://orcid.org/0000-0001-6044-5923)
Institutions
- Physical Sciences (United States) (US)
- October 6 University (EG)
- Jazan University (SA)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2024-11-07
- DOI
- https://doi.org/10.2174/0113816128337881241016064641
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00