Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway
Cardiovascular diseases (CVDs) remain a key contributor to global morbidity and mortality. Being a vital regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) is a crucial player in CVD treatment. Recently, increasing attention has been paid to the effect of natural drugs on CVDs. According to some studies, HIF-1α is a potential target for CVD treatment in traditional Chinese medicine. In this study, we describe the mechanism underlying the regulatory role of HIF-1α in CVDs and summarize 30 natural drugs and 3 formulations for CVD treatment through HIF-1α and its signaling pathway. The study provides new ideas for CVD prevention and treatment.
Authors
- Danyang Wang (ORCID: https://orcid.org/0000-0003-3471-4231)
- Yu Sun (ORCID: https://orcid.org/0000-0003-0333-2898)
- Jinlan Deng (ORCID: https://orcid.org/0000-0002-7925-0429)
- Xiayinan Song
- Min Zhang (ORCID: https://orcid.org/0000-0003-3489-6442)
- Jie Li (ORCID: https://orcid.org/0000-0002-6513-5702)
- Yanmei Shi (ORCID: https://orcid.org/0000-0001-9758-1013)
- Weihan Gao
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2024-11-07
- DOI
- https://doi.org/10.2174/0113862073331615241018081811
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57