Composition and Biological Activity of Flavonoid-containing Fractions of an Extractfrom Gratiola officinalis L.
The antitumor effect of the most active fraction containing 7-O-glucoside of apigenin, glycoside 7,3'-di-O-luteolin and trace amounts of eupatilin against renal carcinoma A498 cells was manifested in its cytotoxic, cytostatic, apoptotic and autophagosomal activities. In addition, we found 3-(1-2)-glucoside of soyaspogenol B, which is a pentacyclic triterpenoid in the structure.
Authors
- Alexander Shirokov (ORCID: https://orcid.org/0000-0003-4321-735X)
- Matvey Kanevskiy (ORCID: https://orcid.org/0000-0002-5932-6748)
- А. В. Полуконова (ORCID: https://orcid.org/0000-0001-7198-1254)
- L. Yu. Matora (ORCID: https://orcid.org/0000-0001-5654-8292)
- Vyacheslav S. Grinev (ORCID: https://orcid.org/0000-0002-0627-6804)
- Yu. P. Fedonenko (ORCID: https://orcid.org/0000-0003-0255-8190)
- Н. В. Полуконова (ORCID: https://orcid.org/0000-0001-9228-6808)
- Д. А. Мудрак (ORCID: https://orcid.org/0000-0001-7399-9204)
- Galina N. Maslyakova (ORCID: https://orcid.org/0000-0001-8834-1536)
- Artyom M. Mylnikov (ORCID: https://orcid.org/0000-0003-2433-8228)
- Nikita Navolokin (ORCID: https://orcid.org/0000-0001-7876-9758)
- Alla B. Bucharskaya (ORCID: https://orcid.org/0000-0003-0503-6486)
Institutions
- Saratov State University (RU)
- Institute of Biochemistry and Physiology of Plants and Microorganisms (RU)
- Saratov State Medical University (RU)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2024-11-07
- DOI
- https://doi.org/10.2174/0118715206323280241029215900
- Citations
- 4
- Primary Topic
- Agriculture and Biological Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.37