<i>Amphiregulin</i> is overexpressed in human cardiac tissue in hypothermia deaths; associations between the transcript and stress hormone levels in cardiac deaths
Severe hypothermia activates cardiac <i>AREG</i> expression practicable as a postmortem hypothermia marker. Cortisol and catecholamines may act as transcriptional modifiers of this gene, especially in long-term ischaemic heart disease. However, the exact role of these hormones in upregulation of <i>AREG</i> during hypothermia remains unclear.
Authors
- Katja Porvari (ORCID: https://orcid.org/0000-0002-5692-243X)
- Kie Horioka (ORCID: https://orcid.org/0000-0002-9218-4905)
- Lasse Pakanen (ORCID: https://orcid.org/0000-0002-3494-7652)
- Helena Kaija (ORCID: https://orcid.org/0000-0003-1715-7023)
Institutions
- Finnish Institute for Health and Welfare (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1080/07853890.2024.2420862
- Citations
- 5
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Oulun Yliopisto