Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases

Our data suggests that AL04 can be used as an AD prophylactic/therapeutic agent as it lowers the hyperphosphorylated tau by downregulating I2PP2A. We also propose that AL04 can induce the degradation of hyperphosphorylated tau aggregates through the upregulation of the autophagy pathway.

Authors

Publication Details

Journal
IBRO Neuroscience Reports
Published
2024-11-07
DOI
https://doi.org/10.1016/j.ibneur.2024.11.005
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases

Jeong Kuen Song, Sookhee Bang, Kwan Hee Lee
IBRO Neuroscience Reports
Alzheimer's disease research and treatments
article

Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases

Jeong Kuen Song, Sookhee Bang, Kwan Hee Lee
article en

Abstract

Our data suggests that AL04 can be used as an AD prophylactic/therapeutic agent as it lowers the hyperphosphorylated tau by downregulating I2PP2A. We also propose that AL04 can induce the degradation of hyperphosphorylated tau aggregates through the upregulation of the autophagy pathway.

IBRO Neuroscience ReportsVol. 17
Zero hunger
Openalex Percentile: Top 72%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases — Jeong Kuen Song, Sookhee Bang, et al. · IBRO Neuroscience Reports (2024) | TGRS Research Map | TGRS