Structural brain connectivity does not associate with childhood trauma in individuals with schizophrenia
CT did not impact on topology or subnetwork connectivity changes in SZ. High CT levels were also not associated with any differences in network organisation irrespective of diagnosis. However, our findings confirm that SZ showed both network-level reductions and increases in a subnetwork. These findings suggest that the patterns of neuroanatomical dysconnectivity in established schizophrenia may not be influenced by CT. Future studies are needed to investigate the association between CT and structural dysconnectivity in schizophrenia.
Authors
- Gary J Donohoe (ORCID: https://orcid.org/0000-0003-3037-7426)
- Brian P. Hallahan (ORCID: https://orcid.org/0000-0003-0518-9757)
- Emma Corley (ORCID: https://orcid.org/0000-0002-3296-925X)
- Wee Xuan Neo
- Laurena Holleran (ORCID: https://orcid.org/0000-0002-8354-3670)
- David Mothersill (ORCID: https://orcid.org/0000-0003-3013-4088)
- Maria R. Dauvermann (ORCID: https://orcid.org/0000-0002-2873-8512)
- Dara M. Cannon (ORCID: https://orcid.org/0000-0001-7378-3411)
- Leila Nabulsi (ORCID: https://orcid.org/0000-0001-9448-7769)
- Colm McDonald (ORCID: https://orcid.org/0000-0003-1661-5192)
- Pramath Kakodkar (ORCID: https://orcid.org/0000-0002-5288-1247)
- Laura Costello (ORCID: https://orcid.org/0000-0003-1921-5821)
- Andrea Fernandes
- Genevieve Mc Philemy
Institutions
- Ollscoil na Gaillimhe – University of Galway (IE)
- Cognitive Neuroimaging Lab (FR)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.jpsychires.2024.10.030
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science Foundation Ireland
- Irish Research Council
- European Research Council
- H2020 European Research Council