p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury
In summary, our study suggests that the p53/HIF-1α signaling pathway plays a critical role in regulating neuronal aging and autophagy in the pathogenesis of SCI. Importantly, HIF-1α may represent a promising therapeutic target for SCI treatment.
Authors
- Xingzhen Liu (ORCID: https://orcid.org/0000-0003-1382-6453)
- Jia Wang (ORCID: https://orcid.org/0009-0006-9377-8779)
- Wenjie Jin
- Kangping Shen
Institutions
- XinHua Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Mechanisms of Ageing and Development
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.mad.2024.112000
- Citations
- 4
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China