Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether purinergic P2Y<sub>14</sub> receptor contributes to EA-mediated analgesia remains unclear. Here, we report that the expression of P2Y<sub>14</sub> receptor in the hindlimb region of the primary somatosensory cortex (S1HL) was significantly upregulated on Complete Freund's Adjuvant (CFA)-induced pain model mice, while was downregulated after EA treatment (2 Hz frequency, 1 mA intensity, and 30 min duration) at "Zusanli" (also named ST36 acupoint). EA-mediated analgesia could be reversed by injection of P2RY<sub>14</sub> agonist uridine diphosphate glucose (UDPG) into the bilateral S1HL, while prolonged by injection of P2RY<sub>14</sub> antagonist pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid (PPTN). It suggested that EA may alleviate inflammatory pain by downregulating the expression of P2RY<sub>14</sub> in the S1HL.
Authors
- Shuguang Yu (ORCID: https://orcid.org/0000-0002-1413-8989)
- Xiaoxiao Zhao (ORCID: https://orcid.org/0000-0001-8384-1734)
- Cui-Yuan Chen
- Ruizhu Zhou
- Shuai Hou (ORCID: https://orcid.org/0000-0001-5274-5264)
- Haiyan Yin (ORCID: https://orcid.org/0000-0002-5442-5210)
- Sha Yang (ORCID: https://orcid.org/0000-0003-0345-5740)
- Shasha Chen
- Liuxuan He
Institutions
- Chengdu University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Purinergic Signalling
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1007/s11302-024-10058-3
- Citations
- 4
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province