Engineering Mesoscale T Cell Receptor Clustering by Plug‐and‐Play Nanotools (Adv. Mater. 45/2024)
Engineering Mesoscale T Cell Receptors In article number 2310407, Robert Tampé and co-workers introduce innovative nanotools to control T cell receptor (TCR) clustering, crucial for immune recognition. By comparing ligand-induced and ligand-free conditions, researchers discovered that architecture significantly impacts TCR assembly. This approach enhances our understanding of TCR activation, paving the way for advanced immunotherapies, including CAR T cell therapies. Image credit: M.F. Sánchez & R. Tampé, Institute of Biochemistry, Goethe University Frankfurt.
Authors
- Robert Tampé (ORCID: https://orcid.org/0000-0002-0403-2160)
- Christian Winter (ORCID: https://orcid.org/0000-0002-1616-9260)
- Peter Lanzerstorfer (ORCID: https://orcid.org/0000-0003-4512-7964)
- Birgit Plochberger (ORCID: https://orcid.org/0000-0003-2733-9947)
- Tina Karimian
- Julian Weghuber (ORCID: https://orcid.org/0000-0001-6312-4666)
- M. Florencia Sánchez (ORCID: https://orcid.org/0000-0003-1049-0368)
- Stefan Frühschulz (ORCID: https://orcid.org/0009-0008-1640-089X)
- Sevi Faria
- Lars Werkmann
Institutions
- Goethe University Frankfurt (DE)
- Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
- University of Applied Sciences Upper Austria (AT)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1002/adma.202470356
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00