One-Step Palladium-Catalyzed Heterocyclic Ring Closure of Benzofurans with Aryl Iodides through a Heck-Type Pathway
An operationally simple and robust method for the direct arylation and ring closure of benzofurans is reported. Besides the mild conditions and good reaction yields, the methodology is applicable for a wide range of derivatives using commercially available aryl iodides with complete C<sub>2</sub> regioselectivity. The reaction is proposed to follow a Heck-type oxyarylation mechanism. The facile synthesis method will enable the development of new materials for diverse applications in biology and catalysis and as precursors for organic semiconductors.
Authors
- Nivedha Velmurugan
- Fathy Hassan (ORCID: https://orcid.org/0000-0001-9379-8434)
- Yusuke Yamane (ORCID: https://orcid.org/0000-0003-4919-8719)
- Síle Nic Chormaic (ORCID: https://orcid.org/0000-0003-4276-2014)
- Christine K. Luscombe (ORCID: https://orcid.org/0000-0001-7456-1343)
Institutions
- Okinawa Institute of Science and Technology Graduate University (JP)
- Keio University (JP)
- Tanta University (EG)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1021/acs.orglett.4c03602
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Keio University
- Okinawa Institute of Science and Technology Graduate University
- Tanta University
- Japan Society for the Promotion of Science