Chromosome level assemblies of Nakaseomyces (Candida) bracarensis uncover two distinct clades and define its adhesin repertoire
N. bracarensis clinical isolates belong to at least two differentiated clades. We describe a novel repeat motif found in N. bracarensis adhesins, which helps in their identification. Adhesins underwent independent expansions in N. glabratus and N. bracarensis, leading to repertoires that are qualitatively different but quantitatively similar. Given that adhesins are considered virulence factors, some of the observed differences could contribute to variations in virulence capabilities between N. glabratus and N. bracarensis.
Authors
- Marina Marcet‐Houben (ORCID: https://orcid.org/0000-0003-4838-187X)
- Ewa Księżopolska (ORCID: https://orcid.org/0000-0002-2021-4343)
- Toni Gabaldón
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Barcelona Supercomputing Center (ES)
- Centro de Investigación Biomédica en Red (ES)
- Institute for Research in Biomedicine (ES)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12864-024-10979-8
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- “la Caixa” Foundation
- Instituto Potosino de Investigación Científica y Tecnológica
- HORIZON EUROPE European Research Council