Seasonal and climatic influence on respiratory infections in children with cystic fibrosis

Pseudomonas aeruginosa (Pa) and Methicillin susceptible Staphylococcus aureus (MSSA) are the predominant bacteria found in the airways of people with cystic fibrosis (pwCF), significantly contributing to lung disease progression. While various factors influencing the initial acquisition (IA) of these pathogens are known, the impact of environmental conditions remains understudied. This epidemiological study assessed the risk of MSSA and Pa initial acquisitions in relation to seasonality and climatic zones among 1,184 French pwCF under 18 years old. The age at IA for Pa (Pa-IA) and MSSA (MSSA-IA) was estimated using the Kaplan-Meier method. Seasonality and climatic zones were analysed as risk factors using time-varying Cox regression models. The median age at MSSA-IA was notably earlier (2.0 years) than that at Pa-IA (5.1 years). MSSA-IA occurred increasingly younger in more recent birth cohorts, while the age at Pa-IA remained stable over time. The risk of Pa-IA was consistently higher in all seasons compared with spring, peaking in autumn (HR = 1.53), irrespective of climatic zones. In Oceanic and Continental climates, the highest risk for MSSA-IA was in winter (HRs = 1.45 and 1.20 respectively). In the Mediterranean climate, the risk of MSSA-IA was lower in winter compared to spring (HRs = 0.68 and 0.61 respectively), and the median age at MSSA-IA later than for Pa-IA. This study demonstrates that seasonality and meteorological factors may influence acquisition of MSSA and Pa in pwCF. These findings suggest that environmental factors play a role in pathogen acquisition dynamics in CF and could inform the development of preventive strategies.

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Journal
Scientific Reports
Published
2024-11-07
DOI
https://doi.org/10.1038/s41598-024-77253-5
Primary Topic
Cystic Fibrosis Research Advances
Type
article
Field-Weighted Citation Impact
0.00

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article

Seasonal and climatic influence on respiratory infections in children with cystic fibrosis

Pierre‐Yves Boëlle, S. Dominique, Loïc Guillot, Katia Bessaci et al.
Scientific Reports
Cystic Fibrosis Research Advances
article

Seasonal and climatic influence on respiratory infections in children with cystic fibrosis

Pierre‐Yves Boëlle, S. Dominique, Loïc Guillot, Katia Bessaci, M. Murris‐Espin, Sophie Ramel, Nathalie Stremler, Laurent Mély, Harriet Corvol, M. Gérardin, I. Durieu, Emmanuelle Coirier-Duet, Isabelle Sermet‐Gaudelus, Muriel Laurans, Sandra Dury, Olivier Le Rouzic, Laure Cosson, Philippe Reix, S. Bui, Isabelle Pin, Nadine Dufeu, Cinthia Rames, Julie Macey, Martine Reynaud‐Gaubert, Alice Ladaurade, D. Hubert, P. Le Roux, Valérie David, Aurélie Tatopoulos, Karine Campbell, Caroline Périsson, Baptiste Arnouat, Nadia Nathan, Michaël Fayon, Philippe Domblides, Sylvie Leroy, Julie Mésinèle, Manon Ruffin, M Héraud, Françoise Troussier, Marie Mittaine, À. Munck, Bénédicte Richaud-Thiriez, Guillaume Thouvenin, Nathalie Allou, Tiphaine Bihouee, C. Belleguic, Yves Billon, R. Chiron, Manuëla Scalbert-Dujardin, J. Languepin, Frédéric Huet, Dominique Grenet, Ralph Epaud, G. Rault, Pierre‐Régis Burgel, Romain Kessler, J.‐C. Dubus, V. Storni, B. Camara, Véronique Houdouin, Laurence Weiss, Nathalie Wizla, Isabelle Danner‐Boucher, Philippe Vigneron, Annlyse Fanton, P. Foucaud, Jacques Brouard, E. Deneuville, Jean‐Louis Giniès, Raphaëlle Nové-Josserand, Natacha Rémus, Christophe Marguet, Carole Bailly Piccini, Marie-Laure Dalphin, François Brémont, Julie Mankikian, Cathie Llerena, Michel Abelly
article en

Abstract

Pseudomonas aeruginosa (Pa) and Methicillin susceptible Staphylococcus aureus (MSSA) are the predominant bacteria found in the airways of people with cystic fibrosis (pwCF), significantly contributing to lung disease progression. While various factors influencing the initial acquisition (IA) of these pathogens are known, the impact of environmental conditions remains understudied. This epidemiological study assessed the risk of MSSA and Pa initial acquisitions in relation to seasonality and climatic zones among 1,184 French pwCF under 18 years old. The age at IA for Pa (Pa-IA) and MSSA (MSSA-IA) was estimated using the Kaplan-Meier method. Seasonality and climatic zones were analysed as risk factors using time-varying Cox regression models. The median age at MSSA-IA was notably earlier (2.0 years) than that at Pa-IA (5.1 years). MSSA-IA occurred increasingly younger in more recent birth cohorts, while the age at Pa-IA remained stable over time. The risk of Pa-IA was consistently higher in all seasons compared with spring, peaking in autumn (HR = 1.53), irrespective of climatic zones. In Oceanic and Continental climates, the highest risk for MSSA-IA was in winter (HRs = 1.45 and 1.20 respectively). In the Mediterranean climate, the risk of MSSA-IA was lower in winter compared to spring (HRs = 0.68 and 0.61 respectively), and the median age at MSSA-IA later than for Pa-IA. This study demonstrates that seasonality and meteorological factors may influence acquisition of MSSA and Pa in pwCF. These findings suggest that environmental factors play a role in pathogen acquisition dynamics in CF and could inform the development of preventive strategies.

Scientific ReportsVol. 14(1)
Hôpital Necker-Enfants Malades (FR), Inserm (FR), Centre Hospitalier Universitaire de Grenoble (FR), Centre Hospitalier Universitaire de Bordeaux (FR), Centre Hospitalier Universitaire de Lille (FR), Centre Hospitalier Universitaire de Nice (FR), Centre Hospitalier Universitaire de Nantes (FR), Centre Hospitalier Universitaire de Toulouse (FR), Sorbonne Université (FR), Hôpital Armand-Trousseau (FR), Centre Hospitalier Universitaire de La Réunion (RE), Centre Hospitalier Universitaire de Besançon (FR), Hôpital Cochin (FR), Centre Hospitalier Universitaire de Tours (FR), ManRos Therapeutics (France) (FR), Assistance Publique – Hôpitaux de Paris (FR), Centre Hospitalier de Bretagne Sud (FR), Centre Hospitalier Régional et Universitaire de Nancy (FR), Hospices Civils de Lyon (FR), Hôpital Saint-Antoine (FR), Centre Hospitalier de Vitré (FR), Hôpital d'Enfants (FR), Centre Hospitalier Universitaire de Reims (FR), Centre hospitalier Bretagne Atlantique (FR), Hôpital Renée Sabran (FR), Centre Hospitalier Universitaire d'Angers (FR), Centre Hospitalier Universitaire de Caen Normandie (FR), Hôpital Nord (FR), CHU Dijon Bourgogne (FR), Centre Hospitalier Universitaire de Limoges (FR), Hôpital André Mignot (FR), Groupe Hospitalier du Havre (FR), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR), Centre de Recherche Saint-Antoine (FR), Hôpital Arnaud de Villeneuve (FR), Centre Hospitalier Universitaire de Rouen (FR), Centre Hospitalier Universitaire de Rennes (FR), Hôpital Foch (FR), Neovacs (France) (FR), Hôpital Intercommunal de Créteil (FR), Hôpital de la Timone (FR), Université de Rouen Normandie (FR), Université de Reims Champagne-Ardenne (FR), Université de Caen Normandie (FR)
Institut National de la Santé et de la Recherche Médicale, Association Vaincre la Mucoviscidose
Openalex Percentile: Top 62%
Cystic Fibrosis Research Advances
DOIOpen Access PDFOpenAlex
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