Human umbilical cord mesenchymal stem cells restore chemotherapy-induced premature ovarian failure by inhibiting ferroptosis in vitro ovarian culture system
This study confirms that cisplatin-induced ovarian damage via ferroptosis in vitro POF model, and hUCMSCs repair ovarian injury by inhibiting the ferroptosis pathway and suppressing fibrosis. This research contributes to evaluating the effectiveness of hUCMSCs in treating chemotherapy-induced POF by inhibiting ferroptosis in an in vitro ovarian culture system and provides a potential therapeutic strategy for chemotherapy-induced POF.
Authors
- Fengyu Zhu (ORCID: https://orcid.org/0009-0004-1975-2234)
- Fei Zhong (ORCID: https://orcid.org/0000-0002-6280-9644)
- Yumiao Kang
- Wenjuan Xu (ORCID: https://orcid.org/0009-0001-3096-3778)
- Zhuoying He
- Jiaqi Chen (ORCID: https://orcid.org/0000-0003-3091-4471)
- Heng Tang (ORCID: https://orcid.org/0000-0002-8965-6588)
- Jianye Wang
Institutions
- Anhui Medical University (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Academy of Coal Science (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12958-024-01310-x
- Citations
- 5
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Anhui Medical University
- Anhui Provincial Key Research and Development Plan