Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy
GDF15 is a plasma marker that responds to the treatment of unresected LA-NSCLC with cCRT and metformin. GDF15 levels correspond with tumor volume and increased GDF15 levels predict for poor RFS and OS. These results require validation in larger clinical trial datasets.
Authors
- Anand Swaminath (ORCID: https://orcid.org/0000-0003-4013-1980)
- Theodoros Tsakiridis (ORCID: https://orcid.org/0000-0002-8675-4422)
- Mario J. Valdés (ORCID: https://orcid.org/0000-0002-5137-0293)
- James Wright (ORCID: https://orcid.org/0009-0008-3205-8916)
- Gordon Okawara
- Elham Ahmadi (ORCID: https://orcid.org/0000-0003-0472-4615)
- Olga‐Demetra Biziotis (ORCID: https://orcid.org/0000-0002-7838-5938)
- Wilson Roa (ORCID: https://orcid.org/0000-0002-1727-840X)
- Amr Ali (ORCID: https://orcid.org/0000-0002-1750-0605)
- Gregory R. Pond (ORCID: https://orcid.org/0000-0003-1033-0882)
- Bassam Abdulkarim (ORCID: https://orcid.org/0000-0002-0372-0412)
- Peter Ellis (ORCID: https://orcid.org/0000-0003-1590-2130)
- Andrew Robinson (ORCID: https://orcid.org/0000-0003-1152-4275)
- Marcin Wierzbicki
- Evangelia E. Tsakiridis
- Gregory R. Steinberg (ORCID: https://orcid.org/0000-0001-5425-8275)
- Fiorella Di Pastena (ORCID: https://orcid.org/0000-0003-3509-8936)
- Peter A. Kavsak (ORCID: https://orcid.org/0000-0003-4576-4744)
- André G. Gouveia (ORCID: https://orcid.org/0000-0001-7055-3557)
- Naseer Ahmed (ORCID: https://orcid.org/0000-0002-2225-6045)
Institutions
- Queen's University (CA)
- Juravinski Cancer Centre (CA)
- Grand River Hospital (CA)
- McMaster University Medical Centre (CA)
- Ontario Clinical Oncology Group (CA)
- CancerCare Manitoba (CA)
- McGill University (CA)
- McMaster University (CA)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s13014-024-02546-y
- Citations
- 5
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.35
Funders
- Hamilton Health Sciences Foundation
- Canadian Institutes of Health Research