SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma
SLC38A5 promotes osteosarcoma cell proliferation, migration, and invasion via the glutamine-mediated PI3K/AKT/mTOR signaling pathway and inhibits ferroptosis. Targeting SLC38A5 and the PI3K/AKT signaling axis may provide a meaningful therapeutic strategy for the future treatment of osteosarcoma.
Authors
- Kezhou Xia
- Wenda Liu
- Zhun Wei (ORCID: https://orcid.org/0000-0002-8699-3749)
- Weichun Guo (ORCID: https://orcid.org/0000-0001-8991-6362)
- Zicheng Wei (ORCID: https://orcid.org/0000-0003-2909-3290)
- Xinghan Huang
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1186/s12967-024-05803-6
- Citations
- 17
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.97