Physicochemical and spectroscopic analysis of interactions between aspirin and normal saline at different temperatures

• Molecular interactions in aspirin–normal saline system were studied • Thermo–acoustic parameters were obtained and analysed • UV–Spectral studies were used to support thermo–acoustic studies • Reducing and antioxidative behavior of aspirin was observed from cyclic voltammetry • Dominance of ion-hydrophilic interactions was observed in these systems • Aspirin behaves as a structure–maker in normal saline The primary goal of the current investigation is to explore the molecular interactions between the aspirin (2-Acetoxybenzoic acid) and normal saline (0.9% w/v aqueous NaCl) at various concentrations (0.001–0.010) m and temperature (T= 300.15–315.15) K. To understand the various possible molecular interactions, volumetric, acoustic, conductometric and viscometric parameters were evaluated using experimental measured values of densities ( ρ ), ultrasonic velocities ( u ), specific conductance (κ), and viscosities ( η ). The results derived from these parameters have been examined in terms of drug–solvent and drug-drug interactions. The results of physicochemical studies indicate that aspirin exhibits strong interactional and structure–forming behaviour in normal saline. These results were well supported by UV-visible spectral studies which indicate the existence of intense aspirin–normal saline interactions in the form of modification in absorption maximum and absorption wavelength. The cyclic voltammetric studies were also performed to explore the oxidation/reduction behaviour and effect of aspirin on hemolysis. The experimental analysis of these studies provides valuable insights for better drug design, drug delivery, compatibility, potential safety, and biological relevance for the pharmaceutical and health industries.