Reverse the Age Clock: Reverse Clinical Signs of Ageing with Epigenetic Skin Science

During this symposium, an expert panel comprising both practising dermatologists and leading figures in epigenetics research discussed the development of an innovative new approach to treating facial skin ageing based on the underlying science of epigenetics. Frank Lyko, Professor of Epigenetics at the University of Heidelberg, Germany, explored the epigenetic processes that drive skin ageing and highlighted how the reversibility of the DNA methylation changes may provide novel opportunities for intervention. Elke Grönniger and Julia Gallinger from Beiersdorf AG, Germany introduced the skin-specific age clock as an AI-based algorithm to determine the biological age of skin and to search for new ingredients which can reverse the skin age. They outlined how this led to the discovery of the key active ingredient (Epicelline®, Beiersdorf, Hamburg, Germany) in the new Hyaluron-Filler Epigenetic Serum (Eucerin®), a breakthrough epigenetic innovation that is able to visibly reverse ten clinical signs of skin ageing. Firas Al-Niaimi, Professor in laser dermatology at St John’s Institute of Dermatology, London, UK, discussed the potential for Epicelline to be combined with other anti-ageing aesthetic procedures, such as fractionated laser, due to synergistic effects on the expression of youthful genes. Finally, Hassan Galadari, Associate Professor of Dermatology at the United Arab Emirates University, provided case study examples showing the successful use of Epicelline in combination treatment with chemical peel, microneedling, and injectables in real-world clinical practice.