Comparative Study on the Hypoglycemic Effects of Different Parts of <i>Musa balbisiana</i>

Diabetes mellitus is a chronic metabolic disorder that can cause elevated blood glucose levels due to impaired insulin secretion or resistance. Different parts of <i>Musa balbisiana</i> have been used widely in traditional medicine to treat many disorders. The present study aims to evaluate the antidiabetic ability of the corm, pseudostem, inflorescence, fruit, peel, and seed of <i>M. balbisiana</i> via in vitro experiments by inhibiting α-amylase and α-glucosidase enzymes as well as in vivo models on diabetic alloxan-induced mice. The results show that all investigated parts have performed potential inhibition on two investigated digestive enzymes. Seed poses the highest capacity among surveyed parts on α-amylase (IC₅₀:f μg/mL) and α-glucosidase (IC₅₀: 21.63 μg/mL) as well as effectively lowers the blood glucose index (IG) in alloxan-induced mice. In addition, fruit, corm, and inflorescence are considered essential parts that have high hypoglycemic effects via in vivo experiments. These findings indicate that all <i>M. balbisiana</i> parts are possibly a potential source for hypoglycemic agents; further clinical studies are needed to evaluate the safety of human beings before applying them in functional food and pharmaceutical industries.