Quantum entangle in a zinc ion pair of RNA-dependent RNA polymerase of flaviviruses and its role in the polymerization reaction

The flavivirus polymerase protein undergoes structural changes during the polymerization reaction. The protein contains two zinc atoms, each of which is coordinated by four amino acids of the protein. The possibility of a quantum transition in zinc atoms is considered. It is shown that due to quantum entanglement this transition occurs jointly in both atoms. Using molecular dynamics modeling, it is shown that small perturbations of the structure associated with the joint transition of zinc atoms lead to structural changes in the polymerase. The prevalence of this phenomenon on other zinc-containing proteins is discussed.