Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice
These results suggest that the expression of engineered PC via neonatal genome editing is a potential cure for severe congenital PC deficiency.
Authors
- Yuji Kashiwakura (ORCID: https://orcid.org/0000-0003-0585-3937)
- Tsukasa Ohmori (ORCID: https://orcid.org/0000-0001-5082-6394)
- Osamu Nureki (ORCID: https://orcid.org/0000-0003-1813-7008)
- Eriko Morishita (ORCID: https://orcid.org/0000-0001-9116-3363)
- Takafumi Hiramoto (ORCID: https://orcid.org/0000-0003-4054-6748)
- Takayuki Fujiwara (ORCID: https://orcid.org/0000-0002-8719-3997)
- Tomoki Togashi (ORCID: https://orcid.org/0000-0002-2600-657X)
- Morisada Hayakawa (ORCID: https://orcid.org/0000-0002-1869-2450)
- Nemekhbayar Baatartsogt (ORCID: https://orcid.org/0000-0002-3004-8457)
- Yasumitsu Nagao (ORCID: https://orcid.org/0009-0001-3888-6682)
Institutions
- Kanazawa University (JP)
- Jichi Medical University (JP)
- Kanazawa Medical University (JP)
- University of Tokyo Hospital (JP)
- Department of Biological Sciences (RU)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1161/atvbaha.123.319460
- Citations
- 3
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- University of Pennsylvania
- Jichi Medical University